NetworKIN

Map of the human phosphorylation network

Kinases are shown in orange and substrates in blue.

The background colour of each gene symbol is shaded according to the number of predicted site-specific interactions.

A darker background indicates a higher number of targets/substrates, i.e. a scale of kinases with an increasing number of substrates looks like this:

1^FGR 459^MAPK1 917^CDK2 1376^GSK3B

Conversely a scale of substrates with an increasing number of predicted kinases looks like this:

1_GIT1 25_MINK 49_ABL1 74_SRRM2

Click on a gene symbol to select it. Both that protein and its predicted matches (substrates for a kinase and kinases for a substrate) will become highlighted in green. Clicking on a highlighted protein will de-select itself and its predicted matches.

Highlighted proteins can be seen in a "String context" (the network of associated proteins). More details about bar-graph views can be found on our help page.

Please note that, when selecting many substrates/kinases, timeouts might occur during String Context presentation.

If you use any of the data from this web site please cite this article: Linding et al., Systematic discovery of in vivo phosphorylation networks. Cell. 2007 Jun 29;129(7):1415-26.

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ABL1 AKT1 AKT2 AKT3 ATM BLK BMX BTK CAMK2A CAMK2B CAMK2D CAMK2G CDC2 CDC42BPA CDK2 CDK3 CDK5 CK2A1 CLK1 CLK2 CLK3 CLK4 CSF1R CSNK1A1 CSNK1A1L CSNK1D CSNK1E CSNK1G1 CSNK1G2 CSNK1G3 CSNK2A2 DMPK EGFR ERBB2 ERBB3 ERBB4 FGFR1 FGFR2 FGFR3 FGR FRK FYN GSK3A GSK3B HCK IGF1R INSR INSRR ITK KIT LCK LYN MAPK1 MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPK7 MAPK8 MAPK9 PCTK1 PCTK2 PDGFRA PDGFRB PFTK1 PKACA PKN1 PKN2 PKN3 PNCK PRKACB PRKACG PRKCA PRKCB1 PRKCD PRKCE PRKCG PRKCH PRKCI PRKCQ PRKCZ PRKDC PRKG1 PRKG2 PRKX PRKY PTK6 ROCK1 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA4 RPS6KA5 RPS6KA6 RPS6KB1 RPS6KB2 RPS6KC1 SGK SGK2 SGK3 SRC TEC TXK YES1 ENSP00000339005 ENSP00000339209

AACS AAK1 AANAT AASDHPPT AAT1 AATF ABCA1 ABCA2 ABCB1 ABCB3 ABCB4 ABCB9 ABCC1 ABCC4 ABCC5 ABCD3 ABCF1 ABHD10 ABI1 ABL1 ABLIM1 ABLIM3 ACACA ACAD10 ACAD9 ACADSB ACCN1 ACE ACE2 ACIN1 ACLY ACO1 ACO2 ACOX1 ACP1 ACR ACSS1 ACSS2 ACTA1 ACTL6A ACTL7B ACTN1 ACTN4 ACTR1A ACTR1B ACTR2 ACTR3 ADAM15 ADAM17 ADAM22 ADAM9 ADAR ADCY4 ADCY6 ADCY9 ADD2 ADD3 ADNP ADRA2A ADRB1 ADRB2 ADRBK1 ADRBK2 ADRM1 ADSS AEBP2 AFF1 AGGF1 AGL AGPAT1 AGTPBP1 AGTR1 AGTR2 AGTRAP AHCY AHI1 AHNAK AHR AICDA AKAP1 AKAP11 AKAP12 AKAP13 AKAP3 AKAP4 AKAP8 AKAP8L AKAP9 AKNA AKR1C3 AKR1C4 AKT1 AKT2 AKT3 ALB ALDH1A1 ALDH7A1 ALDOA ALK ALMS1 ALOX5 ALPI ALS2 ALS2CR11 ALS2CR19 ALS2CR3 ALS4 AMHR2 AMOT AMOTL1 AMPD2 AMPH ANAPC1 ANAPC2 ANAPC4 ANAPC5 ANAPC7 ANK1 ANK2 ANK3 ANKHD1 ANKRD11 ANKRD12 ANKRD13 ANKRD17 ANKRD2 ANKRD25 ANKS1 ANLN ANP32A ANP32B ANP32E ANTXR1 ANXA1 ANXA2 ANXA4 ANXA5 ANXA6 ANXA9 AOF2 AOP2 AP1GBP1 AP3B1 AP3D1 AP4E1 APAF1 APBA2 APBB1 APC APEH API5 APLP2 APMAP APOBEC1 APP APPL1 APRIN APRT APTX APXL AQP0 AQP1 AQP2 AQP4 ARAF ARD1A ARF1GAP ARFGAP3 ARFGEF1 ARFGEF2 ARFIP2 ARHGAP1 ARHGAP12 ARHGAP15 ARHGAP18 ARHGAP21 ARHGAP23 ARHGAP26 ARHGAP5 ARHGAP6 ARHGAP7 ARHGDIA ARHGEF1 ARHGEF11 ARHGEF12 ARHGEF17 ARHGEF18 ARHGEF2 ARHGEF5 ARHGEF6 ARHGEF7 ARHGEF8 ARID1A ARID3A ARID4A ARID4B ARID5B ARIH2 ARL2BP ARL6IP4 ARMCX3 ARMET ARNT ARPC5L ARPP19 ARPP21 ARRB1 ARRB2 ARS2 ARVCF ASCC2 ASCC3L1 ASGR2 ASMTL ASPM ASPSCR1 ASXL2 ASZ1 ATAD2 ATBF1 ATE1 ATF1 ATF2 ATF4 ATF7 ATF7IP ATIC ATM ATN1 ATP11C ATP13A3 ATP1A1 ATP2A2 ATP2B1 ATP2B4 ATP6AP1 ATP6V0A2 ATP6V0D1 ATP6V1C1 ATP6V1D ATP6V1G2 ATP8B3 ATRX ATXN1 ATXN2L ATXN7 ATXN7L2 AUP1 AURKB AURKC AUTS2 AVEN AVPR2 AXIN1 AXIN2 AXL AZI1 B3GALT3 BACE1 BACH2 BAD BAG2 BAG3 BAG4 BAI2 BAI3 BAIAP2 BAIAP2L1 BANF1 BARD1 BARX2 BASP1 BAT2 BAT2D1 BAT3 BATF BAX BAZ1A BAZ1B BAZ2A BAZ2B BCAR1 BCAR3 BCCIP BCDO2 BCKDHA BCL10 BCL2 BCL2L1 BCL2L11 BCL2L12 BCL2L13 BCL6 BCL7A BCL7B BCL9 BCL9L BCLAF1 BCR BCS1L BDR2 BEGAIN BET1 BICD1 BICD2 BID BIK BIN1 BIRC4 BIRC5 BIRC6 BLK BLM BLNK BLOC1S3 BLVRA BM28 BMP2K BMX BNC BNIP3L BOLA1 BOP1 BPY2IP1 BRAF BRAP BRCA1 BRCA2 BRD1 BRD2 BRD3 BRD4 BRD7 BRD8 BRF BRPF1 BRRN1 BRSK1 BRSK2 BRWD3 BSCL2 BSG BSN BSP1 BTAF1 BTK BUB1 BUB1B BUB3 BXDC2 BYSL BZW1 BZW2 C10orf118 C10orf119 C10orf12 C10orf6 C12orf11 C14orf106 C14orf133 C14orf24 C14orf32 C14orf4 C18orf25 C18orf8 C1orf43 C1orf48 C1orf77 C1QA C20orf129 C20orf130 C20orf172 C20orf72 C20orf77 C21orf70 C22orf19 C3 C5orf13 C5R1 C6orf166 C9orf10 C9orf16 C9orf25 C9orf5 CA10 CABIN1 CABLES1 CABYR CACNA1A CACNA1B CACNA1D CACNA1H CACNB1 CACNB2 CACNB3 CADPS2 CALB2 CALD1 CALM1 CALML5 CALU CAMK2A CAMK2D CAMK2G CAMK4 CAMKK1 CAMKK2 CAML1 CANX CAPN1 CAPN2 CAPZA1 CARD11 CARHSP1 CARS CASB CASC3 CASC5 CASP1 CASP2 CASP3 CASP6 CASP8 CASP8AP2 CASP9 CASQ2 CASR CAST CAV1 CAV2 CBFA2T2 CBFA2T3